Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Revenues
Total revenues	$ 268,306,000	$ 210,637,000	$ 771,466,000	$ 602,970,000
Cost and expenses
Research and development	77,235,000	65,510,000	237,714,000	228,504,000
Selling, general and administrative	154,742,000	147,667,000	456,877,000	444,769,000
Total cost and expenses	379,288,000	329,689,000	1,133,175,000	1,002,237,000
Loss from operations	(110,982,000)	(119,052,000)	(361,709,000)	(399,267,000)
Interest expense	(3,252,000)	(2,330,000)	(9,490,000)	(6,567,000)
Interest and other income, net	5,406,000	87,000	14,509,000	1,165,000
Loss before income taxes	(108,828,000)	(121,295,000)	(356,690,000)	(404,669,000)
Income tax expense	(202,000)	(185,000)	(80,000)	(557,000)
Net loss	(109,030,000)	(121,480,000)	(356,770,000)	(405,226,000)
Unrealized gain (loss) on available-for-sale securities, net of tax	3,807,000	(3,212,000)	10,966,000	(17,322,000)
Comprehensive loss	$ (105,223,000)	$ (124,692,000)	$ (345,804,000)	$ (422,548,000)
Net Loss per Share
Basic (in dollars per share)	$ (0.95)	$ (1.25)	$ (3.14)	$ (4.20)
Diluted (in dollars per share)	$ (0.95)	$ (1.25)	$ (3.14)	$ (4.20)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	115,171	97,052	113,559	96,408
Diluted (in shares)	115,171	97,052	113,559	96,408
Product
Revenues
Total revenues	$ 265,218,000	$ 199,831,000	$ 761,271,000	$ 584,415,000
Cost and expenses
Cost of revenues	146,962,000	115,436,000	437,524,000	326,862,000
Licensing and other
Revenues
Total revenues	3,088,000	10,806,000	10,195,000	18,555,000
Cost and expenses
Cost of revenues	$ 349,000	$ 1,076,000	$ 1,060,000	$ 2,102,000