Condensed Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Common stock	Additional Paid-in Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Total
Balance at Dec. 31, 2021	$ 10	$ 2,050,417	$ (2,287)	$ (1,394,836)	$ 653,304
Balance (in shares) at Dec. 31, 2021	95,140
Issuance of common stock upon exercise of stock options		4,578			4,578
Issuance of common stock upon exercise of stock options (in shares)	701
Issuance of common stock under employee stock purchase plan		8,496			8,496
Issuance of common stock under employee stock purchase plan (in shares)	285
Vesting of restricted stock units (in shares)	777
Stock based compensation		76,060			76,060
Unrealized gain (loss) on available-for sale securities			(14,110)		(14,110)
Net loss				(283,746)	(283,746)
Balance at Jun. 30, 2022	$ 10	2,139,551	(16,397)	(1,678,582)	444,582
Balance (in shares) at Jun. 30, 2022	96,903
Balance at Mar. 31, 2022	$ 10	2,089,660	(13,904)	(1,533,431)	542,335
Balance (in shares) at Mar. 31, 2022	96,259
Issuance of common stock upon exercise of stock options		422			422
Issuance of common stock upon exercise of stock options (in shares)	70
Issuance of common stock under employee stock purchase plan		8,496			8,496
Issuance of common stock under employee stock purchase plan (in shares)	285
Vesting of restricted stock units (in shares)	289
Stock based compensation		40,973			40,973
Unrealized gain (loss) on available-for sale securities			(2,493)		(2,493)
Net loss				(145,151)	(145,151)
Balance at Jun. 30, 2022	$ 10	2,139,551	(16,397)	(1,678,582)	444,582
Balance (in shares) at Jun. 30, 2022	96,903
Balance at Dec. 31, 2022	$ 11	2,664,730	(16,362)	(1,942,635)	$ 705,744
Balance (in shares) at Dec. 31, 2022	111,255				111,255
Issuance of common stock upon exercise of stock options		2,939			$ 2,939
Issuance of common stock upon exercise of stock options (in shares)	217
Issuance of common stock under employee stock purchase plan		8,674			8,674
Issuance of common stock under employee stock purchase plan (in shares)	219
Issuance of common stock for IPR&D milestone		14,435			14,435
Issuance of common stock for IPR&D milestone (in shares)	336
Vesting of restricted stock units (in shares)	1,675
Stock based compensation		85,165			85,165
Issuance of common stock for bonuses		19,771			19,771
Issuance of common stock for bonuses (in shares)	349
Unrealized gain (loss) on available-for sale securities			7,159		7,159
Net loss				(247,740)	(247,740)
Balance at Jun. 30, 2023	$ 11	2,795,714	(9,203)	(2,190,375)	$ 596,147
Balance (in shares) at Jun. 30, 2023	114,051				114,051
Balance at Mar. 31, 2023	$ 11	2,741,932	(11,798)	(2,079,572)	$ 650,573
Balance (in shares) at Mar. 31, 2023	113,359
Issuance of common stock upon exercise of stock options		638			638
Issuance of common stock upon exercise of stock options (in shares)	48
Issuance of common stock under employee stock purchase plan		8,674			8,674
Issuance of common stock under employee stock purchase plan (in shares)	219
Vesting of restricted stock units (in shares)	425
Stock based compensation		44,470			44,470
Unrealized gain (loss) on available-for sale securities			2,595		2,595
Net loss				(110,803)	(110,803)
Balance at Jun. 30, 2023	$ 11	$ 2,795,714	$ (9,203)	$ (2,190,375)	$ 596,147
Balance (in shares) at Jun. 30, 2023	114,051				114,051