Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenues
Total revenues	$ 261,404,000	$ 198,200,000	$ 503,160,000	$ 392,333,000
Cost and expenses
Research and development	78,173,000	82,580,000	160,479,000	162,994,000
Selling, general and administrative	152,508,000	149,468,000	302,135,000	297,102,000
Total cost and expenses	373,830,000	341,285,000	753,887,000	672,548,000
Loss from operations	(112,426,000)	(143,085,000)	(250,727,000)	(280,215,000)
Interest expense	(3,177,000)	(2,150,000)	(6,238,000)	(4,237,000)
Interest and other income, net	4,518,000	277,000	9,103,000	1,078,000
Loss before income taxes	(111,085,000)	(144,958,000)	(247,862,000)	(283,374,000)
Income tax benefit (expense)	282,000	(193,000)	122,000	(372,000)
Net loss	(110,803,000)	(145,151,000)	(247,740,000)	(283,746,000)
Unrealized gain (loss) on available-for-sale securities, net of tax	2,595,000	(2,493,000)	7,159,000	(14,110,000)
Comprehensive loss	$ (108,208,000)	$ (147,644,000)	$ (240,581,000)	$ (297,856,000)
Net Loss per Share
Basic (in dollars per share)	$ (0.97)	$ (1.50)	$ (2.20)	$ (2.95)
Diluted (in dollars per share)	$ (0.97)	$ (1.50)	$ (2.20)	$ (2.95)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	113,690	96,579	112,734	96,081
Diluted (in shares)	113,690	96,579	112,734	96,081
Product
Revenues
Total revenues	$ 258,256,000	$ 194,582,000	$ 496,053,000	$ 384,584,000
Cost and expenses
Cost of revenues	142,808,000	108,756,000	290,562,000	211,426,000
Licensing and other
Revenues
Total revenues	3,148,000	3,618,000	7,107,000	7,749,000
Cost and expenses
Cost of revenues	$ 341,000	$ 481,000	$ 711,000	$ 1,026,000