Condensed Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Common stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Total
Balance at Dec. 31, 2021	$ 10	$ 2,050,417	$ (2,287)	$ (1,394,836)	$ 653,304
Balance (in shares) at Dec. 31, 2021	95,140
Issuance of common stock upon exercise of stock options		4,156			4,156
Issuance of common stock upon exercise of stock options (in shares)	631
Vesting of restricted stock units (in shares)	488
Stock based compensation		35,087			35,087
Unrealized gain (loss) on available-for sale securities			(11,617)		(11,617)
Net loss				(138,595)	(138,595)
Balance at Mar. 31, 2022	$ 10	2,089,660	(13,904)	(1,533,431)	542,335
Balance (in shares) at Mar. 31, 2022	96,259
Balance at Dec. 31, 2022	$ 11	2,664,730	(16,362)	(1,942,635)	$ 705,744
Balance (in shares) at Dec. 31, 2022	111,255				111,255
Issuance of common stock upon exercise of stock options		2,301			$ 2,301
Issuance of common stock upon exercise of stock options (in shares)	169
Issuance of common stock for IPR&D acquisition		14,435			14,435
Issuance of common stock for IPR&D acquisition (in shares)	336
Vesting of restricted stock units (in shares)	1,250
Stock based compensation		40,695			40,695
Issuance of common stock for bonus		19,771			19,771
Issuance of common stock for bonus (in shares)	349
Unrealized gain (loss) on available-for sale securities			4,564		4,564
Net loss				(136,937)	(136,937)
Balance at Mar. 31, 2023	$ 11	$ 2,741,932	$ (11,798)	$ (2,079,572)	$ 650,573
Balance (in shares) at Mar. 31, 2023	113,359				113,359