Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenues
Total revenues	$ 241,756,000	$ 194,133,000
Cost and expenses
Research and development	82,306,000	80,414,000
Selling, general and administrative	149,627,000	147,634,000
Total cost and expenses	380,057,000	331,263,000
Loss from operations	(138,301,000)	(137,130,000)
Interest expense	(3,061,000)	(2,087,000)
Interest and other income, net	4,585,000	801,000
Loss before income taxes	(136,777,000)	(138,416,000)
Income tax expense	(160,000)	(179,000)
Net loss	(136,937,000)	(138,595,000)
Unrealized gain (loss) on available-for-sale securities, net of tax	4,564,000	(11,617,000)
Comprehensive loss	$ (132,373,000)	$ (150,212,000)
Net Loss per Share
Basic (in dollars per share)	$ (1.23)	$ (1.45)
Diluted (in dollars per share)	$ (1.23)	$ (1.45)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	111,767	95,578
Diluted (in shares)	111,767	95,578
Product
Revenues
Total revenues	$ 237,797,000	$ 190,002,000
Cost and expenses
Cost of revenues	147,754,000	102,670,000
Licensing and other
Revenues
Total revenues	3,959,000	4,131,000
Cost and expenses
Cost of revenues	$ 370,000	$ 545,000