Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Operating activities:
Net loss	$ (547,799)	$ (471,716)	$ (229,743)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	16,702	11,254	8,613
Expensed in-process research and development	9,290	35,604
Non-cash lease expense	13,770	10,926	7,834
Stock-based compensation	152,384	115,219	50,171
Inventory reserve adjustments	(240)	628	(163)
Premium amortization and discount accretion on investment securities	4,837	7,814	5,761
Gain (loss) on investments	906	(46)	(105)
Unrealized losses on investment securities	(2)	(11)
Amortization of debt discount and issuance cost	1,259	1,227	149
Other non-cash benefits (charges)	302	94	(149)
Provision for credit losses	1,770	(156)	1,354
Loss on debt extinguishment			5,848
Accretion of Convertible Note			7,048
Changes in operating assets and liabilities:
Accounts receivable	(124,081)	(43,353)	(25,831)
Inventory	(8,257)	(7,506)	(7,474)
Prepaid expenses and other current assets	(1,196)	(249)	(14,393)
Other assets	(6)	(2,933)	(60)
Accounts payable	5,462	19,222	(118)
Accrued compensation	3,069	10,569	14,284
Operating lease liabilities	(9,377)	(10,296)	(8,993)
Other accrued liabilities	47,650	32,682	10,340
Deferred revenue	2,056	(44,209)	(6,895)
Other long-term liabilities			10
Net cash used in operating activities	(431,501)	(335,236)	(182,512)
Investing activities:
Purchases of investments	(86,947)	(876,095)	(685,239)
Proceeds from sale of investments	248,482	187,580	30,067
Proceeds from maturity of investments	216,500	532,910	343,315
Purchases of property and equipment, net	(47,697)	(41,030)	(19,604)
Cash paid for acquisition of an asset		(8,558)
Net cash used in investing activities	330,338	(205,193)	(331,461)
Financing activities:
Proceeds from exercise of stock options	6,411	11,816	23,524
Proceeds from issuance of common stock under employee stock purchase plan	13,037	13,550	7,114
Proceeds from Convertible Note, net of issuance costs			278,316
Loan payment			(78,757)
Proceeds from public offering, net of issuance costs	433,192	550,822	270,650
Proceeds from Credit Line	30,000
Net cash provided by financing activities	482,640	576,188	500,847
Net increase (decrease) in cash equivalents and restricted cash	381,477	35,759	(13,126)
Beginning - cash equivalents & restricted cash	84,614	48,855	61,981
Ending - cash equivalents and restricted cash	466,091	84,614	48,855
Supplemental disclosure of cash flow information:
Cash paid for income taxes	549	283	67
Cash paid for interest	8,060	7,077	3,296
Non-cash investing and financing activities:
Purchases of property and equipment in accounts payable and accruals	$ (1,940)	$ 5,173	$ 2,781