Leases (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($) ft² lease location	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Lessee, Lease, Description [Line Items]
Operating lease liabilities, current portion included in other accrued liabilities	$ 7,639	$ 5,752
Operating Lease, Liability, Current, Statement of Financial Position [Extensible List]	Other Accrued Liability, Current	Other Accrued Liability, Current
Operating lease liabilities, long-term portion	$ 76,577	$ 61,036
Operating lease liabilities	84,216
Noncash investing activities related to right-of-use assets	$ 22,100	44,400
Weighted average remaining lease term	7 years 6 months 10 days
Weighted average discount rate (as a percent)	6.70%
Lease expense	$ 13,800	10,900	$ 7,800
Operating lease payments	$ 9,377	10,296	$ 8,993
Minimum
Lessee, Lease, Description [Line Items]
Term of lease	1 year
Maximum
Lessee, Lease, Description [Line Items]
Term of lease	5 years
Austin TX, Long-term Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	94,000
Number of office space locations | lease	2
Term of lease	132 months
Noncash investing activities related to right-of-use assets	$ 20,100
First Expansion Premises
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	32,500
Second Expansion Premises
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	65,222
Corporate Headquarters Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	136,000
Number of office space locations | location	2
Term of lease	84 months
Renewal term of lease	5 years
"First Space" Sublease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	88,000
"Second Space" Sublease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	48,000
Corporate Headquarters Lease Amendment
Lessee, Lease, Description [Line Items]
Renewal term of lease	48 months
Lease expense	$ 9,300
Tukwila, WA Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	10,000
Term of lease	62 months
Renewal term of lease	5 years
San Carlos, CA Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	25,879
Term of lease	48 months
Noncash investing activities related to right-of-use assets		$ 29,700
Lease expense	$ 1,900
San Carlos, CA Lease | Rentable square feet surrendered in lease amendment
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	25,879
South San Francisco, CA Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	11,395
Term of lease	36 months
Renewal term of lease	3 years
Lease expense	$ 900
Laboratory space in Canada
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	7,107
Annual lease payment	$ 200
Term of lease	24 months