Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Common stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Total
Balance at Dec. 31, 2019	$ 8	$ 976,955	$ 919	$ (699,171)	$ 278,711
Balance (in shares) at Dec. 31, 2019	78,005,000
Issuance of common stock upon exercise of stock options		23,524			23,524
Issuance of common stock upon exercise of stock options (in shares)	2,092,000
Issuance of common stock under employee stock purchase plan		7,114			7,114
Issuance of common stock under employee stock purchase plan (in shares)	234,000
Vesting of restricted stock (in shares)	1,100,000
Stock based compensation		50,171			50,171
Unrealized gain (loss) on available-for sale securities			3,340		3,340
Cumulative-effect adjustment upon adoption				(404)	(404)
Equity component of Convertible Notes, net		82,873			82,873
Issuance of common stock for public offering, net	$ 1	270,649			270,650
Issuance of common stock for public offering, net (in shares)	4,792,000
Net loss				(229,743)	(229,743)
Balance at Dec. 31, 2020	$ 9	1,411,286	4,259	(929,318)	486,236
Balance (in shares) at Dec. 31, 2020	86,223,000
Issuance of common stock upon exercise of stock options		11,816			11,816
Issuance of common stock upon exercise of stock options (in shares)	1,165,000
Issuance of common stock under employee stock purchase plan		13,550			13,550
Issuance of common stock under employee stock purchase plan (in shares)	186,000
Vesting of restricted stock (in shares)	2,117,000
Stock based compensation		115,219			115,219
Unrealized gain (loss) on available-for sale securities			(6,546)		(6,546)
Cumulative-effect adjustment upon adoption		(82,876)		6,198	(76,678)
Issuance of common stock for public offering, net	$ 1	550,821			550,822
Issuance of common stock for public offering, net (in shares)	5,175,000
Issuance of common stock for IPR&D		30,601			30,601
Issuance of common stock for IPR&D (in shares)	274,000
Net loss				(471,716)	(471,716)
Balance at Dec. 31, 2021	$ 10	2,050,417	(2,287)	(1,394,836)	$ 653,304
Balance (in shares) at Dec. 31, 2021	95,140,000				95,140,000
Issuance of common stock upon exercise of stock options		6,411			$ 6,411
Issuance of common stock upon exercise of stock options (in shares)	828,000
Issuance of common stock under employee stock purchase plan		13,037			13,037
Issuance of common stock under employee stock purchase plan (in shares)	437,000
Vesting of restricted stock (in shares)	1,480,000
Stock based compensation		152,384			152,384
Unrealized gain (loss) on available-for sale securities			(14,075)		(14,075)
Issuance of common stock for public offering, net	$ 1	433,191			433,192
Issuance of common stock for public offering, net (in shares)	13,145,000
Issuance of common stock for IPR&D		9,290			9,290
Issuance of common stock for IPR&D (in shares)	225,000
Net loss				(547,799)	(547,799)
Balance at Dec. 31, 2022	$ 11	$ 2,664,730	$ (16,362)	$ (1,942,635)	$ 705,744
Balance (in shares) at Dec. 31, 2022	111,255,000				111,255,000