Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues
Total revenues	$ 820,222	$ 625,486	$ 391,005
Cost and expenses
Research and development	316,415	264,208	100,035
Selling, general and administrative	588,591	511,034	303,627
Total cost and expenses	1,361,262	1,093,660	607,282
Loss from operations	(541,040)	(468,174)	(216,277)
Interest expense	(9,319)	(8,305)	(15,082)
Interest and other income, net	3,538	5,381	7,562
Loss on debt extinguishment			(5,848)
Loss before income taxes	(546,821)	(471,098)	(229,645)
Income tax expense	(978)	(618)	(98)
Net loss	(547,799)	(471,716)	(229,743)
Unrealized loss on available-for-sale securities, net of tax	(14,075)	(6,546)	3,340
Comprehensive loss	$ (561,874)	$ (478,262)	$ (226,403)
Net loss per share (Note 13):
Basic (in dollars per share)	$ (5.57)	$ (5.21)	$ (2.84)
Diluted (in dollars per share)	$ (5.57)	$ (5.21)	$ (2.84)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	98,408	90,558	81,011
Diluted (in shares)	98,408	90,558	81,011
Product
Revenues
Total revenues	$ 797,307	$ 580,080	$ 377,877
Cost and expenses
Cost of revenues	453,632	315,195	200,097
Licensing and other
Revenues
Total revenues	22,915	45,406	13,128
Cost and expenses
Cost of revenues	$ 2,624	$ 3,223	$ 3,523