Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating activities:
Net loss	$ (405,226)	$ (331,152)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	12,772	8,259
Expensed in-process research and development		35,604
Premium amortization and discount accretion on investment securities	3,971	5,707
Stock-based compensation	116,398	84,797
Non-cash lease expense	9,989	8,106
Amortization of debt discount and issuance cost	941	917
Inventory reserve adjustments	(148)	726
Other non-cash benefits	100	133
Provision for credit losses	2,615	380
Unrealized losses on investment securities	(12)
Gain (loss) on investments	532	(58)
Changes in operating assets and liabilities:
Accounts receivable	(116,903)	(32,232)
Inventory	(13,372)	(8,717)
Prepaid expenses and other current assets	686	(254)
Other assets	(200)	(550)
Accounts payable	8,367	183
Accrued compensation	1,285	4,960
Operating lease liabilities	(7,207)	(7,597)
Other accrued liabilities	35,422	34,845
Deferred revenue	(384)	(40,557)
Cash used in operating activities	(350,374)	(236,500)
Investing activities:
Purchases of investments	(86,947)	(674,372)
Proceeds from sale of investments	214,738	77,563
Proceeds from maturity of investments	216,500	348,410
Purchases of property and equipment, net	(35,870)	(32,027)
Cash paid for acquisition of an asset		(4,271)
Cash provided by investing activities	308,421	(284,697)
Financing activities:
Proceeds from exercise of stock options	5,971	10,774
Proceeds from issuance of common stock under employee stock purchase plan	8,496	6,085
Proceeds from public offering, net of issuance costs		550,814
Cash provided by financing activities	14,467	567,673
Net increase in cash, cash equivalents and restricted cash	(27,486)	46,476
Cash, cash equivalents and restricted cash, beginning of period	84,614	48,855
Cash, cash equivalents and restricted cash, end of period	57,128	95,331
Supplemental disclosure of cash flow information:
Cash paid for interest	4,008	3,690
Non-cash investing and financing activities:
Purchases of property and equipment in accounts payable and accruals	$ 458	$ 4,957