Condensed Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Common stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income	Accumulated Deficit	Total
Balance at Dec. 31, 2020	$ 9	$ 1,411,286	$ 4,259	$ (929,318)	$ 486,236
Balance (in shares) at Dec. 31, 2020	86,223
Issuance of common stock upon exercise of stock options		10,774			10,774
Issuance of common stock upon exercise of stock options (in shares)	1,051
Issuance of common stock under employee stock purchase plan		6,085			6,085
Issuance of common stock under employee stock purchase plan (in shares)	106
Vesting of restricted stock units (in shares)	1,707
Stock based compensation		84,797			84,797
Unrealized loss on available-for sale securities			(2,768)		(2,768)
Cumulative-effect adjustment upon adoption of ASU 2020-06		(82,876)		6,198	(76,678)
Issuance of common stock for public offering, net	$ 1	550,821			550,822
Issuance of common stock for public offering, net (in shares)	5,175
Issuance of common stock for IPR&D acquisition		30,901			30,901
Issuance of common stock for IPR&D acquisition (in shares)	276
Net loss				(331,152)	(331,152)
Balance at Sep. 30, 2021	$ 10	2,011,788	1,491	(1,254,272)	759,017
Balance (in shares) at Sep. 30, 2021	94,538
Balance at Jun. 30, 2021	$ 9	1,399,659	2,441	(1,102,999)	299,110
Balance (in shares) at Jun. 30, 2021	88,498
Issuance of common stock upon exercise of stock options		3,945			3,945
Issuance of common stock upon exercise of stock options (in shares)	268
Vesting of restricted stock units		3			3
Vesting of restricted stock units (in shares)	320
Stock based compensation		26,459			26,459
Unrealized loss on available-for sale securities			(950)		(950)
Issuance of common stock for public offering, net	$ 1	550,821			550,822
Issuance of common stock for public offering, net (in shares)	5,176
Issuance of common stock for IPR&D acquisition		30,901			30,901
Issuance of common stock for IPR&D acquisition (in shares)	276
Net loss				(151,273)	(151,273)
Balance at Sep. 30, 2021	$ 10	2,011,788	1,491	(1,254,272)	759,017
Balance (in shares) at Sep. 30, 2021	94,538
Balance at Dec. 31, 2021	$ 10	2,050,417	(2,287)	(1,394,836)	$ 653,304
Balance (in shares) at Dec. 31, 2021	95,140				95,140
Issuance of common stock upon exercise of stock options		5,971			$ 5,971
Issuance of common stock upon exercise of stock options (in shares)	785
Issuance of common stock under employee stock purchase plan		8,496			8,496
Issuance of common stock under employee stock purchase plan (in shares)	285
Vesting of restricted stock units (in shares)	1,090
Stock based compensation		116,398			116,398
Unrealized loss on available-for sale securities			(17,322)		(17,322)
Net loss				(405,226)	(405,226)
Balance at Sep. 30, 2022	$ 10	2,181,282	(19,609)	(1,800,062)	$ 361,621
Balance (in shares) at Sep. 30, 2022	97,300				97,300
Balance at Jun. 30, 2022	$ 10	2,139,551	(16,397)	(1,678,582)	$ 444,582
Balance (in shares) at Jun. 30, 2022	96,903
Issuance of common stock upon exercise of stock options		1,393			1,393
Issuance of common stock upon exercise of stock options (in shares)	84
Vesting of restricted stock units (in shares)	313
Stock based compensation		40,338			40,338
Unrealized loss on available-for sale securities			(3,212)		(3,212)
Net loss				(121,480)	(121,480)
Balance at Sep. 30, 2022	$ 10	$ 2,181,282	$ (19,609)	$ (1,800,062)	$ 361,621
Balance (in shares) at Sep. 30, 2022	97,300				97,300