Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenues
Total revenues	$ 210,637,000	$ 158,116,000	$ 602,970,000	$ 452,458,000
Cost and expenses
Research and development	65,510,000	98,457,000	228,504,000	192,397,000
Selling, general and administrative	147,667,000	128,485,000	444,769,000	364,273,000
Total cost and expenses	329,689,000	308,313,000	1,002,237,000	780,966,000
Loss from operations	(119,052,000)	(150,197,000)	(399,267,000)	(328,508,000)
Interest expense	(2,330,000)	(2,078,000)	(6,567,000)	(6,226,000)
Interest and other income, net	87,000	1,274,000	1,165,000	4,230,000
Loss before income taxes	(121,295,000)	(151,001,000)	(404,669,000)	(330,504,000)
Income tax expense	(185,000)	(272,000)	(557,000)	(648,000)
Net loss	(121,480,000)	(151,273,000)	(405,226,000)	(331,152,000)
Unrealized loss on available-for-sale securities, net of tax	(3,212,000)	(950,000)	(17,322,000)	(2,768,000)
Comprehensive loss	$ (124,692,000)	$ (152,223,000)	$ (422,548,000)	$ (333,920,000)
Net loss per share (Note 12):
Basic (in dollars per share)	$ (1.25)	$ (1.63)	$ (4.20)	$ (3.72)
Diluted (in dollars per share)	$ (1.25)	$ (1.63)	$ (4.20)	$ (3.72)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	97,052	92,558	96,408	89,130
Diluted (in shares)	97,052	92,558	96,408	89,130
Product
Revenues
Total revenues	$ 199,831,000	$ 153,940,000	$ 584,415,000	$ 413,971,000
Cost and expenses
Cost of revenues	115,436,000	80,511,000	326,862,000	221,870,000
Licensing and other
Revenues
Total revenues	10,806,000	4,176,000	18,555,000	38,487,000
Cost and expenses
Cost of revenues	$ 1,076,000	$ 860,000	$ 2,102,000	$ 2,426,000