Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities:
Net loss	$ (283,746)	$ (179,879)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	7,631	5,262
Premium amortization and discount accretion on investment securities	2,960	3,790
Stock-based compensation	76,060	58,335
Non-cash lease expense	6,652	5,357
Amortization of debt discount and issuance cost	625	610
Inventory reserve adjustments	181	612
Other non-cash benefits	39	117
Provision for credit losses	1,501	63
Gain (loss) on investments	203	(35)
Changes in operating assets and liabilities:
Accounts receivable	(87,738)	(21,628)
Inventory	(3,737)	(8,991)
Prepaid expenses and other current assets	4,727	(2,497)
Accounts payable	2,492	12,313
Accrued compensation	(7,982)	471
Operating lease liabilities	(5,528)	(4,992)
Other accrued liabilities	29,525	24,374
Deferred revenue	8,009	(38,721)
Cash used in operating activities	(248,126)	(145,439)
Investing activities:
Purchases of investments	(79,956)	(71,054)
Proceeds from sale of investments	191,939	31,144
Proceeds from maturity of investments	153,500	205,510
Purchases of property and equipment, net	(23,661)	(18,891)
Cash provided by investing activities	241,822	146,709
Financing activities:
Proceeds from exercise of stock options	4,578	6,829
Proceeds from issuance of common stock under employee stock purchase plan	8,496	6,085
Cash provided by financing activities	13,074	12,914
Net increase in cash, cash equivalents and restricted cash	6,770	14,184
Cash, cash equivalents and restricted cash, beginning of period	84,614	48,855
Cash, cash equivalents and restricted cash, end of period	91,384	63,039
Supplemental disclosure of cash flow information:
Cash paid for interest	3,612	3,538
Non-cash investing and financing activities:
Purchases of property and equipment in accounts payable and accruals	$ 2,035	$ 4,688