Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues
Total revenues	$ 198,200,000	$ 142,026,000	$ 392,333,000	$ 294,342,000
Cost and expenses
Research and development	82,580,000	53,752,000	162,994,000	93,940,000
Selling, general and administrative	149,468,000	127,456,000	297,102,000	235,788,000
Total cost and expenses	341,285,000	257,320,000	672,548,000	472,653,000
Loss from operations	(143,085,000)	(115,294,000)	(280,215,000)	(178,311,000)
Interest expense	(2,150,000)	(2,075,000)	(4,237,000)	(4,148,000)
Interest and other income, net	277,000	1,585,000	1,078,000	2,956,000
Loss before income taxes	(144,958,000)	(115,784,000)	(283,374,000)	(179,503,000)
Income tax expense	(193,000)	(242,000)	(372,000)	(376,000)
Net loss	(145,151,000)	(116,026,000)	(283,746,000)	(179,879,000)
Unrealized loss on available-for-sale securities, net of tax	(2,493,000)	(756,000)	(14,110,000)	(1,818,000)
Comprehensive loss	$ (147,644,000)	$ (116,782,000)	$ (297,856,000)	$ (181,697,000)
Net loss per share (Note 12):
Basic (in dollars per share)	$ (1.50)	$ (1.32)	$ (2.95)	$ (2.06)
Diluted (in dollars per share)	$ (1.50)	$ (1.32)	$ (2.95)	$ (2.06)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	96,579	88,077	96,081	87,387
Diluted (in shares)	96,579	88,077	96,081	87,387
Product
Revenues
Total revenues	$ 194,582,000	$ 139,647,000	$ 384,584,000	$ 260,031,000
Cost and expenses
Cost of revenues	108,756,000	75,527,000	211,426,000	141,359,000
Licensing and other
Revenues
Total revenues	3,618,000	2,379,000	7,749,000	34,311,000
Cost and expenses
Cost of revenues	$ 481,000	$ 585,000	$ 1,026,000	$ 1,566,000