Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Operating activities:
Net loss	$ (138,595)	$ (63,853)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	3,002	2,549
Premium amortization and discount accretion on investment securities	1,790	2,097
Stock-based compensation	35,087	23,232
Non-cash lease expense	3,305	2,671
Amortization of debt discount and issuance cost	312	304
Inventory reserve adjustments	128	316
Other non-cash benefits	4	56
Provision for credit losses	331
Unrealized losses on investment securities	(281)
Loss on investments	46
Amortization of other assets	143
Changes in operating assets and liabilities:
Accounts receivable	(46,119)	(8,997)
Inventory	1,732	(3,966)
Prepaid expenses and other current assets	(6,366)	2,455
Accounts payable	(7,557)	(3,310)
Accrued compensation	(8,545)	(4,501)
Operating lease liabilities	(2,765)	(2,486)
Other accrued liabilities	21,336	18,602
Deferred revenue	5,735	(40,045)
Cash used in operating activities	(137,277)	(74,876)
Investing activities:
Purchases of investments	(24,977)	(43,024)
Proceeds from sale of investments	166,895
Proceeds from maturity of investments	81,000	140,024
Purchases of property and equipment, net	(15,885)	(10,260)
Cash provided by investing activities	207,033	86,740
Financing activities:
Proceeds from exercise of stock options	4,156	4,570
Cash provided by financing activities	4,156	4,570
Net increase in cash, cash equivalents and restricted cash	73,912	16,434
Cash, cash equivalents and restricted cash, beginning of period	84,614	48,855
Cash, cash equivalents and restricted cash, end of period	158,526	65,289
Supplemental disclosure of cash flow information:
Cash paid for interest	159	152
Non-cash investing and financing activities:
Purchases of property and equipment in accounts payable and accruals	$ 2,096	$ 1,898