Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues
Total revenues	$ 194,133,000	$ 152,316,000
Cost and expenses
Research and development	80,414,000	40,188,000
Selling, general and administrative	147,634,000	108,332,000
Total cost and expenses	331,263,000	215,333,000
Loss from operations	(137,130,000)	(63,017,000)
Interest expense	(2,087,000)	(2,073,000)
Interest and other income, net	801,000	1,371,000
Loss before income taxes	(138,416,000)	(63,719,000)
Income tax expense	(179,000)	(134,000)
Net loss	(138,595,000)	(63,853,000)
Unrealized loss on available-for-sale securities, net of tax	(11,617,000)	(1,062,000)
Comprehensive loss	$ (150,212,000)	$ (64,915,000)
Net loss per share (Note 12):
Basic (in dollars per share)	$ (1.45)	$ (0.74)
Diluted (in dollars per share)	$ (1.45)	$ (0.74)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	95,578	86,689
Diluted (in shares)	95,578	86,689
Product
Revenues
Total revenues	$ 190,002,000	$ 120,384,000
Cost and expenses
Cost of revenues	102,670,000	65,832,000
Licensing and other
Revenues
Total revenues	4,131,000	31,932,000
Cost and expenses
Cost of revenues	$ 545,000	$ 981,000