Leases (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($) ft² lease location	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Lessee, Lease, Description [Line Items]
Operating lease liabilities, current portion included in other accrued liabilities	$ 5,752	$ 7,300
Operating Lease, Liability, Current, Statement of Financial Position [Extensible List]	Other Accrued Liability, Current	Other Accrued Liability, Current
Operating lease liabilities, long-term portion	$ 61,036	$ 21,246
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible List]	Operating lease liabilities, long-term portion
Operating lease liabilities	$ 66,788
Noncash investing activities related to right-of-use assets	$ 44,400
Weighted average remaining lease term	4 years 9 months 7 days
Weighted average discount rate (as a percent)	6.40%
Lease expense	$ 10,900	7,800	$ 7,800
Impairment of right-of-use assets			400
Operating lease payments	$ 10,300	$ 9,000	$ 8,600
Minimum
Lessee, Lease, Description [Line Items]
Term of lease	1 year
Maximum
Lessee, Lease, Description [Line Items]
Term of lease	5 years
Austin TX, Long-term Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	94,000
Number of office space locations | lease	2
Term of lease	132 months
First Expansion Premises
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	32,500
Second Expansion Premises
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	65,222
Corporate Headquarters Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	113,000
Number of office space locations | location	2
Term of lease	84 months
Renewal term of lease	5 years
"First Space" Sublease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	88,000
"Second Space" Sublease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	25,000
Corporate Headquarters Lease Amendment
Lessee, Lease, Description [Line Items]
Renewal term of lease	48 months
Lease expense	$ 9,300
Tukwila, WA Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	10,000
Term of lease	62 months
Renewal term of lease	5 years
San Carlos, CA Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	25,879
Term of lease	48 months
Noncash investing activities related to right-of-use assets	$ 29,700
Lease expense	$ 1,900
San Carlos, CA Lease | Rentable square feet surrendered in lease amendment
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	25,879
South San Francisco, CA Lease
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	11,395
Term of lease	36 months
Lease expense	$ 900
Laboratory space in Canada
Lessee, Lease, Description [Line Items]
Office space (area) | ft²	7,107
Annual lease payment	$ 200
Term of lease	24 months