Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues
Total revenues	$ 625,486	$ 391,005	$ 302,328
Cost and expenses
Research and development	264,208	100,035	51,357
Selling, general and administrative	511,034	303,627	206,176
Gain from disposal of business			(14,388)
Total cost and expenses	1,093,660	607,282	418,615
Loss from operations	(468,174)	(216,277)	(116,287)
Interest expense	(8,305)	(15,082)	(10,693)
Interest and other income, net	5,381	7,562	4,152
Loss on debt extinguishment		(5,848)
Loss before income taxes	(471,098)	(229,645)	(122,828)
Income tax expense	(618)	(98)	(1,999)
Net loss	(471,716)	(229,743)	(124,827)
Unrealized gain (loss) on available-for-sale securities, net of tax	(6,546)	3,340	1,471
Comprehensive loss	$ (478,262)	$ (226,403)	$ (123,356)
Net loss per share (Note 14):
Basic (in dollars per share)	$ (5.21)	$ (2.84)	$ (1.79)
Diluted (in dollars per share)	$ (5.21)	$ (2.84)	$ (1.79)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	90,558	81,011	69,555
Diluted (in shares)	90,558	81,011	69,555
Product
Revenues
Total revenues	$ 567,149	$ 367,211	$ 269,881
Cost and expenses
Cost of revenues	302,663	185,865	162,604
Licensing and other
Revenues
Total revenues	58,337	23,794	32,447
Cost and expenses
Cost of revenues	$ 15,755	$ 17,755	$ 12,866