Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenues
Total revenues	$ 158,116,000	$ 98,143,000	$ 452,458,000	$ 278,627,000
Cost and expenses
Research and development	98,457,000	26,421,000	192,397,000	67,651,000
Selling, general and administrative	128,485,000	75,678,000	364,273,000	209,547,000
Total cost and expenses	308,313,000	153,920,000	780,966,000	420,936,000
Loss from operations	(150,197,000)	(55,777,000)	(328,508,000)	(142,309,000)
Interest expense	(2,078,000)	(4,270,000)	(6,226,000)	(10,772,000)
Interest and other income, net	1,274,000	1,749,000	4,230,000	5,661,000
Loss on debt extinguishment				(5,848,000)
Loss before income taxes	(151,001,000)	(58,298,000)	(330,504,000)	(153,268,000)
Income tax expense	(272,000)	(25,000)	(648,000)	(63,000)
Net loss	(151,273,000)	(58,323,000)	(331,152,000)	(153,331,000)
Unrealized gain (loss) on available-for-sale securities, net of tax	(950,000)	(600,000)	(2,768,000)	4,251,000
Comprehensive loss	$ (152,223,000)	$ (58,923,000)	$ (333,920,000)	$ (149,080,000)
Net loss per share (Note 12):
Basic and diluted (in dollars per share)	$ (1.63)	$ (0.72)	$ (3.72)	$ (1.93)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic and diluted (in shares)	92,558	80,908	89,130	79,430
Product
Revenues
Total revenues	$ 150,651,000	$ 93,286,000	$ 406,265,000	$ 260,746,000
Cost and expenses
Cost of revenues	76,838,000	46,873,000	211,387,000	131,124,000
Licensing and other
Revenues
Total revenues	7,465,000	4,857,000	46,193,000	17,881,000
Cost and expenses
Cost of revenues	$ 4,533,000	$ 4,948,000	$ 12,909,000	$ 12,614,000