Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Revenues
Total revenues	$ 142,026,000	$ 86,472,000	$ 294,342,000	$ 180,484,000
Cost and expenses
Research and development	53,752,000	23,005,000	93,940,000	41,230,000
Selling, general and administrative	127,456,000	68,188,000	235,788,000	133,869,000
Total cost and expenses	257,320,000	138,132,000	472,653,000	267,016,000
Loss from operations	(115,294,000)	(51,660,000)	(178,311,000)	(86,532,000)
Interest expense	(2,075,000)	(4,038,000)	(4,148,000)	(6,502,000)
Interest and other income, net	1,585,000	1,924,000	2,956,000	3,911,000
Loss on debt extinguishment		(5,848,000)		(5,848,000)
Loss before income taxes	(115,784,000)	(59,622,000)	(179,503,000)	(94,971,000)
Income tax expense	(242,000)	(15,000)	(376,000)	(38,000)
Net loss	(116,026,000)	(59,637,000)	(179,879,000)	(95,009,000)
Unrealized gain (loss) on available-for-sale securities, net of tax	(756,000)	104,000	(1,818,000)	4,851,000
Comprehensive loss	$ (116,782,000)	$ (59,533,000)	$ (181,697,000)	$ (90,158,000)
Net loss per share (Note 12):
Basic and diluted (in dollars per share)	$ (1.32)	$ (0.75)	$ (2.06)	$ (1.21)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic and diluted (in shares)	88,077	79,069	87,387	78,681
Product
Revenues
Total revenues	$ 137,232,000	$ 80,414,000	$ 255,614,000	$ 167,460,000
Cost and expenses
Cost of revenues	73,227,000	42,731,000	134,549,000	84,251,000
Licensing and other
Revenues
Total revenues	4,794,000	6,058,000	38,728,000	13,024,000
Cost and expenses
Cost of revenues	$ 2,885,000	$ 4,208,000	$ 8,376,000	$ 7,666,000