Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Revenues
Total revenues	$ 152,316,000	$ 94,012,000
Cost and expenses
Research and development	40,188,000	18,225,000
Selling, general and administrative	108,332,000	65,681,000
Total cost and expenses	215,333,000	128,884,000
Loss from operations	(63,017,000)	(34,872,000)
Interest expense	(2,073,000)	(2,464,000)
Interest and other income, net	1,371,000	1,987,000
Loss before income taxes	(63,719,000)	(35,349,000)
Income tax expense	(134,000)	(23,000)
Net loss	(63,853,000)	(35,372,000)
Unrealized gain (loss) on available-for-sale securities, net of tax	(1,062,000)	4,747,000
Comprehensive loss	$ (64,915,000)	$ (30,625,000)
Net loss per share (Note 12):
Basic and diluted (in dollars per share)	$ (0.74)	$ (0.45)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic and diluted (in shares)	86,689	78,287
Product
Revenues
Total revenues	$ 118,382,000	$ 87,046,000
Cost and expenses
Cost of revenues	61,322,000	41,520,000
Licensing and other
Revenues
Total revenues	33,934,000	6,966,000
Cost and expenses
Cost of revenues	$ 5,491,000	$ 3,458,000