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Debt (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 55 Months Ended
Apr. 29, 2019
Dec. 31, 2018
Aug. 14, 2017
Aug. 08, 2017
Apr. 30, 2019
Mar. 31, 2020
Mar. 31, 2019
Mar. 31, 2020
Dec. 31, 2019
Aug. 31, 2017
Sep. 30, 2015
Debt Instrument [Line Items]                      
Issuance of common stock to Orbimed (in shares) 25,000                    
Common stock, shares issued           78,652,000   78,652,000 78,005,000    
Amortization of debt discount           $ 121 $ 98        
Interest expense           2,464 2,724        
Debt principal balance           75,000   $ 75,000 $ 75,000    
Less: unamortized debt discount           (2,119)   (2,119) (1,344)    
Net carrying amount at end of period           72,881   72,881 $ 73,656    
Line Of Credit-UBS                      
Debt Instrument [Line Items]                      
Maximum borrowing capacity                     $ 50,000
Outstanding balance           49,000   49,000      
Accrued interest               1,100      
Interest expense           $ 300 400        
Line Of Credit-UBS | LIBOR                      
Debt Instrument [Line Items]                      
Spread on interest rate (as a percent)           1.10%          
Noncurrent assets                      
Debt Instrument [Line Items]                      
Debt discount           $ 0   0      
Long-term Debt                      
Debt Instrument [Line Items]                      
Debt discount           900   900      
2017 Term Loan                      
Debt Instrument [Line Items]                      
Maximum borrowing capacity                   $ 100,000  
Remaining borrowing capacity   $ 50,000   $ 25,000 $ 50,000         $ 50,000  
Outstanding balance       $ 75,000              
Interest expense           2,100 $ 2,300        
Additional interest in the event of default (as a percent)       3.00%              
Common stock, shares issued     300,000   25,000         300,000  
Debt instrument, fee amount     $ 2,400                
Stock issued (in dollars per share)     $ 8.16                
Legal fees     $ 300                
Debt discount     2,700                
Debt, increase (decrease)     (2,100)                
Debt principal balance     $ 75,000                
Net carrying amount at end of period           $ 72,900   $ 72,900      
2017 Term Loan | Minimum                      
Debt Instrument [Line Items]                      
Remaining borrowing capacity         $ 25,000            
Prepayment premium (as a percent)       2.50%              
2017 Term Loan | Maximum                      
Debt Instrument [Line Items]                      
Prepayment premium (as a percent)       12.50%              
2017 Term Loan | LIBOR                      
Debt Instrument [Line Items]                      
Spread on interest rate (as a percent)   8.75%   8.75% 8.75%            
Base interest rate (as a percent)   1.00%   1.00% 1.00%            
2017 Term Loan | LIBOR | Scenario of minimum borrowing capacity of drawn                      
Debt Instrument [Line Items]                      
Spread on interest rate (as a percent)   8.25%     8.25%            
Base interest rate (as a percent)   1.00%     1.00%            
2017 Term Loan | Noncurrent assets                      
Debt Instrument [Line Items]                      
Debt instrument, fee amount                   $ 1,200