Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenues
Total revenues	$ 302,328	$ 257,654	$ 209,625
Cost and expenses
Research and development	51,357	51,355	50,064
Selling, general and administrative	206,176	154,872	155,306
Gain from disposal of business	(14,388)
Total cost and expenses	418,615	372,282	344,966
(Loss) income from operations	(116,287)	(114,628)	(135,341)
Interest expense	(10,693)	(10,476)	(4,213)
Interest and other (expense) income, net	4,152	(2,729)	2,380
Loss before income taxes	(122,828)	(127,833)	(137,174)
Income tax expense	(1,999)	(321)	(454)
Net loss	(124,827)	(128,154)	(137,628)
Unrealized gain (loss) on available-for-sale securities, net of tax	1,471	214	(41)
Comprehensive loss	$ (123,356)	$ (127,940)	$ (137,669)
Net loss per share (Note 15):
Basic (in dollars per share)	$ (1.79)	$ (2.22)	$ (2.58)
Diluted (in dollars per share)	$ (1.79)	$ (2.22)	$ (2.59)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	69,555	57,848	53,312
Diluted (in shares)	69,555	57,848	53,604
Product
Revenues
Total revenues	$ 269,881	$ 240,366	$ 203,777
Cost and expenses
Cost of revenues	162,604	158,081	135,508
Licensing and other
Revenues
Total revenues	32,447	17,288	5,848
Cost and expenses
Cost of revenues	$ 12,866	$ 7,974	$ 4,088