Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
Sep. 30, 2019	Sep. 30, 2018
Operating activities
Net loss	$ (89,644)	$ (96,313)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	5,921	5,574
Non-cash lease expense	5,807
Stock-based compensation	20,102	10,138
Premium amortization and discount accretion on investment securities	400	264
Amortization of debt discount	336	293
Interest accrued for borrowings and claims related settlement		189
Inventory excess adjustments	719	230
(Gain) loss on disposal of property and equipment		(12)
Impairment of assets	1,310	1,544
Impairment of right-of-use assets	361
Loss on investments		42
Loss from changes in fair value of warrants		4,119
Provision for doubtful accounts	497	152
Other non-cash (benefits)	(22)
Gain on disposal of business	(14,388)
Changes in operating assets and liabilities
Accounts receivable	(2,491)	(16,460)
Inventory	400	(3,477)
Prepaid expenses and other current assets	(9,321)	2,371
Other assets	(9,299)	302
Accounts payable	(5,194)	967
Accrued compensation	1,569	(13)
Other accrued liabilities	1,683	(3,798)
Deferred revenue	42,864	36,586
Deferred rent, net of current portion		(466)
Net cash used in operating activities	(48,390)	(57,768)
Investing activities
Purchases of investments	(197,009)	(115,066)
Proceeds from sale of investments		37,387
Proceeds from maturity of investments	118,780	52,600
Net proceeds from disposal of business	9,675
Purchases of property and equipment, net	(2,554)	(1,770)
Net cash provided by (used in) investing activities	(71,108)	(26,849)
Financing activities
Proceeds from exercise of stock options	10,416	12,063
Proceeds from issuance of common stock under employee stock purchase plan	2,147	1,855
Proceeds from public offering, net of issuance costs	107,595	96,777
Net cash provided by financing activities	120,158	110,695
Net (decrease) increase in cash, cash equivalents and restricted cash	660	26,078
Cash, cash equivalents and restricted cash, beginning of period	51,004	13,021
Cash, cash equivalents and restricted cash, end of period	51,664	$ 39,099
Supplemental non-cash investing and financing activities:
Obtaining right-of-use assets in exchange for lease liabilities	28,191
Purchases of property and equipment in accounts payable and accruals	$ 56

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