Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues
Total revenues	$ 257,654	$ 209,625	$ 212,512
Cost and expenses
Cost of revenues	158,081	135,508	134,494
Cost of licensing and other revenues	7,974	4,088	1,080
Research and development	51,355	50,064	41,862
Selling, general and administrative	154,872	155,306	136,126
Total cost and expenses	372,282	344,966	313,562
Loss income from operations	(114,628)	(135,341)	(101,050)
Interest expense	(10,476)	(4,213)	(533)
Interest and other (expense) income, net	(2,729)	2,380	1,398
Loss before income taxes	(127,833)	(137,174)	(100,185)
Income tax expense	(321)	(454)	(142)
Net loss	(128,154)	(137,628)	(100,327)
Unrealized gain (loss) on available-for-sale securities, net of tax	214	(41)	691
Comprehensive loss	$ (127,940)	$ (137,669)	$ (99,636)
Net loss per share (Note 13):
Basic (in dollars per share)	$ (2.22)	$ (2.58)	$ (1.95)
Diluted (in dollars per share)	$ (2.22)	$ (2.59)	$ (1.95)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	57,848	53,312	51,576
Diluted (in shares)	57,848	53,604	51,576
Product
Revenues
Total revenues	$ 240,366	$ 203,777	$ 209,406
Licensing and other
Revenues
Total revenues	$ 17,288	$ 5,848	$ 3,106