Summary of Significant Accounting Policies - Pronouncements (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017	Dec. 31, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Accounts receivable	$ 60,397		$ 60,397		$ 44,089
Other accrued liabilities	31,067		31,067		33,257
Accumulated deficit	(542,688)		(542,688)		(446,375)
Total revenues	65,280	$ 55,910	190,689	$ 157,575
Loss from operations	(27,166)	(25,789)	(84,901)	(88,710)
Net loss	$ (29,616)	$ (27,865)	$ (96,313)	$ (90,411)
Net loss per share (Note 12):
Basic (in dollars per share)	$ (0.49)	$ (0.52)	$ (1.71)	$ (1.70)
Diluted (in dollars per share)	$ (0.49)	$ (0.52)	$ (1.71)	$ (1.70)
Operating activities
Net loss			$ (96,313)	$ (90,411)
Changes in operating assets and liabilities:
Accounts receivable			(16,460)	5,746
Net cash (used in) provided by operating activities			(57,768)	(69,696)
Cash, cash equivalents and restricted cash, beginning of period			13,021	16,690
Cash, cash equivalents and restricted cash, end of period	$ 39,099	$ 11,598	39,099	11,598
Product
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues	62,662	54,512	177,284	153,835
Licensing and other
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues	$ 2,618	1,398	$ 13,405	3,740
Accounting Standards Update 2016-18
Changes in operating assets and liabilities:
Net cash (used in) provided by operating activities				(1,047)
Cash, cash equivalents and restricted cash, beginning of period				1,434
Cash, cash equivalents and restricted cash, end of period		387		387
As Previously Reported
Operating activities
Net loss				(90,812)
Changes in operating assets and liabilities:
Accounts receivable				6,147
Net cash (used in) provided by operating activities				(68,649)
Cash, cash equivalents and restricted cash, beginning of period				15,256
Cash, cash equivalents and restricted cash, end of period		11,211		11,211
As Previously Reported | Accounting Standards Update 2014-09
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Accounts receivable					8,252
Other accrued liabilities					33,207
Accumulated deficit					(482,162)
Total revenues		56,656		157,174
Loss from operations		(25,043)		(89,111)
Net loss		$ (27,119)		$ (90,812)
Net loss per share (Note 12):
Basic (in dollars per share)		$ (0.51)		$ (1.71)
Diluted (in dollars per share)		$ (0.51)		$ (1.71)
As Previously Reported | Accounting Standards Update 2014-09 | Product
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues		$ 55,331		$ 153,520
As Previously Reported | Accounting Standards Update 2014-09 | Licensing and other
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues		1,325		3,654
Adoption of ASC 606
Operating activities
Net loss				401
Changes in operating assets and liabilities:
Accounts receivable				(401)
Adoption of ASC 606 | Accounting Standards Update 2014-09
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment					41,600
Accounts receivable					35,837
Other accrued liabilities					50
Accumulated deficit					$ 35,787
Total revenues		(746)		401
Loss from operations		(746)		401
Net loss		$ (746)		$ 401
Net loss per share (Note 12):
Basic (in dollars per share)		$ (0.01)		$ 0.01
Diluted (in dollars per share)		$ (0.01)		$ 0.01
Adoption of ASC 606 | Accounting Standards Update 2014-09 | Product
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues		$ (819)		$ 315
Adoption of ASC 606 | Accounting Standards Update 2014-09 | Licensing and other
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues		$ 73		$ 86