Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
Jun. 30, 2018	Jun. 30, 2017
Operating activities
Net loss	$ (66,697)	$ (62,546)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	3,679	3,620
Stock-based compensation	6,522	5,420
Premium amortization and discount accretion on investment securities	310	515
Amortization of debt discount	195
Inventory excess adjustments	152	187
(Gain) loss on disposal of property and equipment	(12)	12
Impairment of assets	1,544	576
Interest accrued for borrowings	20	399
Loss on investments	32	47
Loss (gain) from changes in fair value of warrants	4,119	(320)
Provision for doubtful accounts	(58)	(240)
Changes in operating assets and liabilities
Accounts receivable	(12,854)	5,383
Inventory	(3,477)	(1,132)
Prepaid expenses and other current assets	1,564	1,349
Other assets	415	223
Accounts payable	(784)	2,028
Accrued compensation	(984)	(2,961)
Other accrued liabilities	(3,752)	7,493
Deferred revenue	35,889	96
Deferred rent, net of current portion	(320)	1,457
Net cash used in operating activities	(34,497)	(38,394)
Investing activities
Purchases of investments	(20,584)	(4,219)
Proceeds from sale of investments	27,895	36,791
Proceeds from maturity of investments	27,600	3,000
Purchases of property and equipment, net	(1,227)	(8,066)
Net cash provided by investing activities	33,684	27,506
Financing activities
Proceeds from exercise of stock options	4,197	939
Proceeds from issuance of common stock under employee stock purchase plan	1,855	1,503
Net cash provided by financing activities	6,052	2,442
Net increase (decrease) in cash, cash equivalents and restricted cash	5,239	(8,446)
Cash, cash equivalents and restricted cash, beginning of period	13,021	16,690
Cash, cash equivalents and restricted cash, end of period	$ 18,260	$ 8,244

The increase (decrease) during the reporting period in the amount of deferred rent expenses incurred but not yet paid.

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Amount of expense related to write-down of receivables to the amount expected to be collected. Includes, but is not limited to, accounts receivable and notes receivable.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

+ References

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