Summary of Significant Accounting Policies - Pronouncements (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Dec. 31, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Accounts receivable	$ 57,002		$ 57,002		$ 44,089
Other accrued liabilities	30,520		30,520		33,257
Accumulated deficit	(513,072)		(513,072)		(446,375)
Total revenues	63,069	$ 52,283	125,409	$ 101,665
Loss from operations	(27,218)	(28,371)	(57,735)	(62,921)
Net loss	$ (33,824)	$ (29,066)	$ (66,697)	$ (62,546)
Net loss per share (Note 12):
Basic (in dollars per share)	$ (0.62)	$ (0.55)	$ (1.23)	$ (1.18)
Diluted (in dollars per share)	$ (0.62)	$ (0.55)	$ (1.23)	$ (1.18)
Operating activities
Net loss			$ (66,697)	$ (62,546)
Changes in operating assets and liabilities:
Accounts receivable			(12,854)	5,383
Net cash (used in) provided by operating activities			(34,497)	(38,394)
Cash, cash equivalents and restricted cash, beginning of period			13,021	16,690
Cash, cash equivalents and restricted cash, end of period	$ 18,260	$ 8,244	18,260	8,244
Product
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues	60,353	50,929	114,622	99,323
Licensing and other
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues	$ 2,716	1,354	$ 10,787	2,342
Accounting Standards Update 2016-18
Changes in operating assets and liabilities:
Net cash (used in) provided by operating activities				(328)
Cash, cash equivalents and restricted cash, beginning of period				1,434
Cash, cash equivalents and restricted cash, end of period		1,106		1,106
As Previously Reported
Operating activities
Net loss				(63,693)
Changes in operating assets and liabilities:
Accounts receivable				6,530
Net cash (used in) provided by operating activities				(38,066)
Cash, cash equivalents and restricted cash, beginning of period				15,256
Cash, cash equivalents and restricted cash, end of period		7,138		7,138
As Previously Reported | Accounting Standards Update 2014-09
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Accounts receivable					8,252
Other accrued liabilities					33,207
Accumulated deficit					(482,162)
Total revenues		53,617		100,518
Loss from operations		(27,037)		(64,068)
Net loss		$ (27,732)		$ (63,693)
Net loss per share (Note 12):
Basic (in dollars per share)		$ (0.52)		$ (1.20)
Diluted (in dollars per share)		$ (0.52)		$ (1.20)
As Previously Reported | Accounting Standards Update 2014-09 | Product
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues		$ 52,276		$ 98,189
As Previously Reported | Accounting Standards Update 2014-09 | Licensing and other
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues		1,341		2,329
Adoption of ASC 606
Operating activities
Net loss				1,147
Changes in operating assets and liabilities:
Accounts receivable				(1,147)
Adoption of ASC 606 | Accounting Standards Update 2014-09
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment					41,600
Accounts receivable					35,837
Other accrued liabilities					50
Accumulated deficit					$ 35,787
Total revenues		(1,334)		1,147
Loss from operations		(1,334)		1,147
Net loss		$ (1,334)		$ 1,147
Net loss per share (Note 12):
Basic (in dollars per share)		$ (0.03)		$ 0.02
Diluted (in dollars per share)		$ (0.03)		$ 0.02
Adoption of ASC 606 | Accounting Standards Update 2014-09 | Product
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues		$ (1,347)		$ 1,134
Adoption of ASC 606 | Accounting Standards Update 2014-09 | Licensing and other
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Total revenues		$ 13		$ 13