Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenues
Total revenues	$ 62,340	$ 49,382
Cost and expenses
Cost of product revenues	39,055	33,088
Research and development	14,340	12,650
Selling, general and administrative	37,925	37,582
Total cost and expenses	92,857	83,932
Loss from operations	(30,517)	(34,550)
Interest expense	(2,389)	(183)
Interest and other income	137	1,300
Loss before income taxes	(32,769)	(33,433)
Income tax expense	(104)	(47)
Net loss	(32,873)	(33,480)
Unrealized (loss) gain on available-for-sale securities, net of tax	(138)	200
Comprehensive loss	$ (33,011)	$ (33,280)
Net loss per share (Note 12):
Basic (in dollars per share)	$ (0.61)	$ (0.63)
Diluted (in dollars per share)	$ (0.61)	$ (0.65)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	54,132	52,758
Diluted (in shares)	54,132	53,043
Product
Revenues
Total revenues	$ 54,269	$ 48,394
Licensing and other
Revenues
Total revenues	8,071	988
Cost and expenses
Cost of product revenues	$ 1,537	$ 612