Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2018

Summary Of Significant Accounting Policies [Line Items]

Schedule of reconciliation of restricted cash

	March 31,		December 31,		March 31,		December 31,
	2018		2017		2017		2016
	(in thousands)
Cash and cash equivalents in balance sheet	$	33,674	$	12,620	$	9,086	$	15,256
Restricted cash, current portion in balance sheet		5,674		59		775		1,092
Restricted cash in other assets in balance sheet		342		342		342		342
Total cash, cash equivalents and restricted cash in statements of cash flows	$	39,690	$	13,021	$	10,203	$	16,690

Schedule of Accumulated Other Comprehensive Loss

	Balance at						Balance at
	December 31,				Reclassification		March 31,
	2017		Increase		Adjustment		2018
	(in thousands)
Unrealized (loss) gain on available-for-sale securities, net of tax	$	(766)	$	(170)	$	32	$	(904)
Total accumulated other comprehensive (loss) income, net of tax	$	(766)	$	(170)	$	32	$	(904)

Accounting Standards Update 2014-09

Summary Of Significant Accounting Policies [Line Items]

Schedule of cumulative-effect adjustment

Upon the adoption of ASC 606, the Company revised the following selected amounts in its condensed consolidated balance sheet from amounts previously reported:

	December 31, 2017
	As Previously		Adoption of
	Reported		ASC 606		As Revised
	(in thousands)
Accounts receivable, net of allowance	$	8,252	$	35,837	$	44,089
Other accrued liabilities		33,207		50		33,257
Accumulated deficit	$	(482,162)	$	35,787	$	(446,375)

Upon the adoption of ASC 606, the Company restated the following selected amounts in its unaudited condensed consolidated statements of operations and comprehensive loss from amounts previously reported:

	Three months ended March 31, 2017
	As Previously		Adoption of
	Reported		ASC 606		As Revised
	(in thousands)
Product revenues	$	45,913	$	2,481	$	48,394
Licensing and other revenues		988		—		988
Total revenues		46,901		2,481		49,382
Loss from operations		(37,031)		2,481		(34,550)
Net loss		(35,961)		2,481		(33,480)
Net loss per share:
Basic		(0.68)		0.05		(0.63)
Diluted	$	(0.70)	$	0.05	$	(0.65)

In November 2016, the FASB issued Accounting Standards Update No. 2016-18 (“ASU 2016-08”), Statement of Cash Flows (Topic 230): Restricted Cash (“ASU 2016-18”). The new guidance requires restricted cash to be combined with cash and cash equivalents when reconciling the beginning and ending balances of cash on the statement of cash flows. Further, the new guidance requires the nature of the restrictions to be disclosed, as well as a reconciliation between the balance sheet and the statement of cash flows on how restricted and unrestricted cash are segregated. The Company adopted this new guidance beginning January 1, 2018 and retroactively adjusted the statements of cash flows for three months ended March 31, 2017 to show the combined result of cash and cash equivalents and restricted cash.

	Three months ended March 31, 2017
	As Previously		Adoption of		Adoption of
	Reported		ASU 2016-18		ASC 606		As Revised
	(in thousands)
Operating activities:
Net loss	$	(35,961)	$	—	$	2,481	$	(33,480)
Changes in operating assets and liabilities:
Accounts receivable		6,019		—		(2,481)		3,538
Net cash used in operating activities		(24,303)		(317)		—		(24,620)
Cash, cash equivalents and restricted cash, beginning of period		15,256		1,434		—		16,690
Cash, cash equivalents and restricted cash, end of period	$	9,086	$	1,117	$	—	$	10,203

Accounting Standards Update 2016-18

Summary Of Significant Accounting Policies [Line Items]

Schedule of cumulative-effect adjustment

	Three months ended March 31, 2017
	As Previously		Adoption of		Adoption of
	Reported		ASU 2016-18		ASC 606		As Revised
	(in thousands)
Operating activities:
Net loss	$	(35,961)	$	—	$	2,481	$	(33,480)
Changes in operating assets and liabilities:
Accounts receivable		6,019		—		(2,481)		3,538
Net cash used in operating activities		(24,303)		(317)		—		(24,620)
Cash, cash equivalents and restricted cash, beginning of period		15,256		1,434		—		16,690
Cash, cash equivalents and restricted cash, end of period	$	9,086	$	1,117	$	—	$	10,203