Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues
Product revenues	$ 205,489	$ 213,968	$ 188,168
Licensing and other revenues	5,450	3,106	2,187
Total revenues	210,939	217,074	190,355
Cost and expenses
Cost of product revenues	135,508	134,494	112,845
Cost of licensing and other revenues	4,088	1,080
Research and development	50,064	41,862	27,711
Selling, general and administrative	155,306	136,126	109,637
Total cost and expenses	344,966	313,562	250,193
(Loss) income from operations	(134,027)	(96,488)	(59,838)
Interest expense	(4,213)	(533)	(3,505)
Interest benefit from changes in the fair value of long term debt			964
Interest and other income (expense), net	2,380	1,398	(7,896)
Loss before income taxes	(135,860)	(95,623)	(70,275)
Income tax expense	(454)	(142)
Net loss	(136,314)	(95,765)	(70,275)
Unrealized (loss) gain on available-for-sale securities, net of tax	(41)	691	(1,416)
Comprehensive loss	$ (136,355)	$ (95,074)	$ (71,691)
Net loss per share (Note 13):
Basic (in dollars per share)	$ (2.56)	$ (1.86)	$ (2.68)
Diluted (in dollars per share)	$ (2.56)	$ (1.86)	$ (2.68)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	53,312	51,576	26,204
Diluted (in shares)	53,604	51,576	26,204