Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues
Product revenues	$ 55,331	$ 53,090	$ 153,520	$ 165,457
Licensing and other revenues	1,325	799	3,654	2,318
Total revenues	56,656	53,889	157,174	167,775
Cost and expenses
Cost of product revenues	33,558	33,761	100,355	97,074
Cost of licensing and other revenues	1,054	500	2,516	500
Research and development	12,609	11,345	37,045	30,403
Selling, general and administrative	34,478	34,938	106,369	98,573
Total cost and expenses	81,699	80,544	246,285	226,550
Loss from operations	(25,043)	(26,655)	(89,111)	(58,775)
Interest expense	(1,477)	(146)	(1,878)	(383)
Interest and other (expense) income, net	(437)	887	450	1,403
Loss before income taxes	(26,957)	(25,914)	(90,539)	(57,755)
Income tax expense	(162)	(103)	(273)	(103)
Net loss	(27,119)	(26,017)	(90,812)	(57,858)
Unrealized gain on available-for-sale securities, net of tax	67	(609)	329	1,750
Comprehensive loss	$ (27,052)	$ (26,626)	$ (90,483)	$ (56,108)
Net loss per share (Note 11):
Basic (in dollars per share)	$ (0.51)	$ (0.50)	$ (1.71)	$ (1.13)
Diluted (in dollars per share)	$ (0.51)	$ (0.50)	$ (1.71)	$ (1.13)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	53,447	52,012	53,100	51,301
Diluted (in shares)	53,447	52,012	53,100	51,301