Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues
Product revenues	$ 52,276	$ 51,231	$ 98,189	$ 112,367
Licensing and other revenues	1,341	753	2,329	1,519
Total revenues	53,617	51,984	100,518	113,886
Cost and expenses
Cost of product revenues	33,709	30,973	66,797	63,313
Cost of licensing and other revenues	850		1,462
Research and development	11,786	10,299	24,436	19,058
Selling, general and administrative	34,309	33,227	71,891	63,635
Total cost and expenses	80,654	74,499	164,586	146,006
Loss from operations	(27,037)	(22,515)	(64,068)	(32,120)
Interest expense	(218)	(122)	(401)	(237)
Interest and other (expense) income, net	(413)	(519)	887	516
Loss before income taxes	(27,668)	(23,156)	(63,582)	(31,841)
Income tax expense	(64)		(111)
Net loss	(27,732)	(23,156)	(63,693)	(31,841)
Unrealized gain on available-for-sale securities, net of tax	62	548	262	2,359
Comprehensive loss	$ (27,670)	$ (22,608)	$ (63,431)	$ (29,482)
Net loss per share (Note 11):
Basic (in dollars per share)	$ (0.52)	$ (0.46)	$ (1.20)	$ (0.63)
Diluted (in dollars per share)	$ (0.52)	$ (0.46)	$ (1.20)	$ (0.63)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	53,088	51,445	52,924	50,942
Diluted (in shares)	53,088	51,445	52,924	50,942