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Summary of Significant Accounting Policies (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Aug. 08, 2017
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Dec. 31, 2016
Dec. 31, 2015
Policies              
Common stock, shares issued   53,208,000   53,208,000   52,665,000  
Net (loss) income   $ (27,732) $ (23,156) $ (63,693) $ (31,841)    
Accumulated deficit   409,541   409,541   $ 345,848  
Cash and cash equivalents   7,138 $ 16,557 7,138 $ 16,557 15,256 $ 28,947
Short-term investments   94,988   94,988   130,860  
Outstanding debt with accrued interest   50,022   50,022   49,624  
Restricted cash              
Restricted cash, current portion   764   764   1,092  
Restricted cash, long term portion   $ 342   $ 342   $ 342  
2017 Term Loan | Subsequent Event              
Policies              
Maximum borrowing capacity $ 100,000            
Available borrowing capacity 75,000            
Remaining borrowing capacity $ 25,000            
Debt instrument, term 84 months            
Common stock, shares issued 300,000            
2017 Term Loan | Base Rate | Subsequent Event              
Policies              
Spread on interest rate (as a percent) 8.75%            
Base interest rate (as a percent) 1.00%