Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues
Product revenues	$ 213,968	$ 188,168	$ 157,308
Licensing and other revenues	3,106	2,187	1,981
Total revenues	217,074	190,355	159,289
Cost and expenses
Cost of product, licensing and other revenues	135,574	112,845	78,396
Research and development	41,862	27,711	17,292
Selling, general and administrative	136,126	109,637	62,936
Total cost and expenses	313,562	250,193	158,624
(Loss) income from operations	(96,488)	(59,838)	665
Interest expense	(533)	(3,505)	(4,219)
Interest benefit from changes in the fair value of long term debt		964	118
Interest and other income (expense), net	1,398	(7,896)	(1,716)
Loss before income taxes	(95,623)	(70,275)	(5,152)
Income tax expense	(142)
Net loss	(95,765)	(70,275)	(5,152)
Unrealized gain (loss) on available-for-sale securities, net of tax	691	(1,416)
Comprehensive loss	$ (95,074)	$ (71,691)	$ (5,152)
Basic and diluted net loss per share (in dollars per share)	$ (1.86)	$ (2.68)	$ (1.07)
Weighted-average number of shares used in computing basic and diluted net loss per share	51,576	26,204	4,800