Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues
Product revenues	$ 53,090	$ 44,423	$ 165,457	$ 135,841
Other revenues	799	498	2,318	1,603
Total revenues	53,889	44,921	167,775	137,444
Cost and expenses
Cost of product revenues	34,261	30,456	97,574	81,032
Research and development	11,345	7,336	30,403	19,707
Selling, general and administrative	34,938	27,870	98,573	79,195
Total cost and expenses	80,544	65,662	226,550	179,934
Loss from operations	(26,655)	(20,741)	(58,775)	(42,490)
Interest Expense	(146)	(1,177)	(383)	(3,391)
Interest benefit (expense) from changes in the fair value of long term debt		1,810		(312)
Interest and other income (expense), net	887	2,478	1,403	(1,122)
Loss before income taxes	(25,914)	(17,630)	(57,755)	(47,315)
Income tax expense	(103)	0	(103)	0
Net loss	(26,017)	(17,630)	(57,858)	(47,315)
Unrealized (loss) gain on available-for-sale securities, net of tax	(609)	36	1,750	36
Comprehensive loss	$ (26,626)	$ (17,594)	$ (56,108)	$ (47,279)
Basic and diluted net loss per share (in dollars per share)	$ (0.50)	$ (0.39)	$ (1.13)	$ (2.53)
Weighted-average number of shares used in computing basic and diluted net loss per share	52,012	44,944	51,301	18,721