Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues
Product revenues	$ 188,168	$ 157,308	$ 54,955
Other revenues	2,187	1,981	216
Total revenues	190,355	159,289	55,171
Cost and expenses
Cost of product revenues	112,845	78,396	37,275
Research and development	27,711	17,292	11,550
Selling, general and administrative	109,637	62,936	31,614
Total cost and expenses	250,193	158,624	80,439
Gain (loss) from operations	(59,838)	665	(25,268)
Interest Expense	(3,505)	(4,219)	(1,873)
Interest expense from accretion of convertible notes			(7,901)
Interest benefit (expense) from changes in the fair value of long term debt	964	118	(2,166)
Other (expense) income, net	(7,896)	(1,716)	98
Net (loss)	(70,275)	(5,152)	(37,110)
Unrealized loss on available-for-sale securities, net of tax	(1,416)
Comprehensive (loss)	$ (71,691)	$ (5,152)	$ (37,110)
Basic and diluted net loss per share (in dollars per share)	$ (2.68)	$ (1.07)	$ (9.66)
Weighted-average number of shares used in computing basic and diluted net loss per share:	26,204	4,800	3,841