Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Revenues
Total revenues	$ 2,306,113	$ 1,696,911	$ 1,082,571
Cost and expenses
Research and development	624,110	404,138	320,678
Selling, general and administrative	1,177,261	841,314	618,307
Amortization of acquired intangible assets	1,720
Total cost and expenses	2,616,024	1,919,205	1,528,816
Loss from operations	(309,911)	(222,294)	(446,245)
Interest expense	(4,069)	(10,685)	(12,638)
Interest and other income, net	45,891	43,248	24,353
Loss before income taxes	(268,089)	(189,731)	(434,530)
Income tax benefit (expense)	59,929	(695)	(271)
Net loss	(208,160)	(190,426)	(434,801)
Unrealized gain on available-for-sale securities and foreign currency translation adjustment	86	2,741	13,277
Comprehensive loss	$ (208,074)	$ (187,685)	$ (421,524)
Net loss per share (Note 15):
Basic (in dollars per share)	$ (1.52)	$ (1.53)	$ (3.78)
Diluted (in dollars per share)	$ (1.52)	$ (1.53)	$ (3.78)
Weighted-average number of shares used in computing basic and diluted net loss per share:
Basic (in shares)	136,721	124,718	114,997
Diluted (in shares)	136,721	124,718	114,997
Product
Revenues
Total revenues	$ 2,295,820	$ 1,685,074	$ 1,068,522
Cost and expenses
Cost of revenues	810,627	672,304	588,564
Licensing and other
Revenues
Total revenues	10,293	11,837	14,049
Cost and expenses
Cost of revenues	$ 2,306	$ 1,449	$ 1,267