<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:ns2="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>SCHEDULE 13G/A</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0000019617</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<coverPageHeader>
<amendmentNo>2</amendmentNo>
<securitiesClassTitle>Common Stock, par value $0.0001 per share</securitiesClassTitle>
<eventDateRequiresFilingThisStatement>12/31/2025</eventDateRequiresFilingThisStatement>
<issuerInfo>
<issuerCik>0001604821</issuerCik>
<issuerName>NATERA, INC.</issuerName>
<issuerCusip>632307104</issuerCusip>
<issuerPrincipalExecutiveOfficeAddress>
<ns2:street1>13011 McCallen Pass</ns2:street1>
<ns2:street2>Building A Suite 100</ns2:street2>
<ns2:city>Austin</ns2:city>
<ns2:stateOrCountry>TX</ns2:stateOrCountry>
<ns2:zipCode>78753</ns2:zipCode>
</issuerPrincipalExecutiveOfficeAddress>
</issuerInfo>
<designateRulesPursuantThisScheduleFiled>
<designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
</designateRulesPursuantThisScheduleFiled>
</coverPageHeader>
<coverPageHeaderReportingPersonDetails>
<reportingPersonName>JPMORGAN CHASE &amp; CO.</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>11614632</soleVotingPower>
<sharedVotingPower>3670.0</sharedVotingPower>
<soleDispositivePower>12812792</soleDispositivePower>
<sharedDispositivePower>11783.0</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>12825640</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>9.1</classPercent>
<typeOfReportingPerson>HC</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<items>
<item1>
<issuerName>NATERA, INC.</issuerName>
<issuerPrincipalExecutiveOfficeAddress>13011 McCallen Pass Building A Suite 100 Austin TX 78753</issuerPrincipalExecutiveOfficeAddress>
</item1>
<item2>
<filingPersonName>JPMORGAN CHASE &amp; CO.</filingPersonName>
<principalBusinessOfficeOrResidenceAddress>270 Park Avenue,,New York, NY 10017</principalBusinessOfficeOrResidenceAddress>
<citizenship>DE</citizenship>
</item2>
<item3>
<notApplicableFlag>N</notApplicableFlag>
<typeOfPersonFiling>HC</typeOfPersonFiling>
</item3>
<item4>
<amountBeneficiallyOwned>12825640</amountBeneficiallyOwned>
<classPercent>9.1</classPercent>
<numberOfSharesPersonHas>
<solePowerOrDirectToVote>11614632</solePowerOrDirectToVote>
<sharedPowerOrDirectToVote>3670</sharedPowerOrDirectToVote>
<solePowerOrDirectToDispose>12812792</solePowerOrDirectToDispose>
<sharedPowerOrDirectToDispose>11783</sharedPowerOrDirectToDispose>
</numberOfSharesPersonHas>
</item4>
<item5>
<notApplicableFlag>Y</notApplicableFlag>
<classOwnership5PercentOrLess>N</classOwnership5PercentOrLess>
</item5>
<item6>
<notApplicableFlag>N</notApplicableFlag>
<ownershipMoreThan5PercentOnBehalfOfAnotherPerson>Not Applicable</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
</item6>
<item7>
<notApplicableFlag>N</notApplicableFlag>
<subsidiaryIdentificationAndClassification>J.P. Morgan Trust Company of Delaware;
J.P. Morgan Securities LLC;
JPMorgan Chase Bank, National Association;
JPMorgan Asset Management (UK) Limited;
J.P. MORGAN SE;
J.P. Morgan (Suisse) SA;
J.P. Morgan Investment Management Inc.;
J.P. Morgan Mansart Management Limited;
J.P. Morgan Wealth Management Solutions Inc;
55I, LLC
</subsidiaryIdentificationAndClassification>
</item7>
<item8>
<notApplicableFlag>N</notApplicableFlag>
<identificationAndClassificationOfGroupMembers>Not Applicable</identificationAndClassificationOfGroupMembers>
</item8>
<item9>
<notApplicableFlag>N</notApplicableFlag>
<groupDissolutionNotice>Not Applicable</groupDissolutionNotice>
</item9>
<item10>
<notApplicableFlag>N</notApplicableFlag>
<certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
</item10>
</items>
<signatureInformation>
<reportingPersonName>JPMORGAN CHASE &amp; CO.</reportingPersonName>
<signatureDetails>
<signature>Rachel Tsvaygoft</signature>
<title>Vice President</title>
<date>01/23/2026</date>
</signatureDetails>
</signatureInformation>
</formData>
</edgarSubmission>
