Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Income Taxes [Line Items]
Increase in valuation allowance tax	$ 88,700
Net operating loss carryforwards, federal	1,064,400
Research and development tax credit carryforwards	$ 94,500
Research and development tax credit carryforwards, expiration year	2035
Net operating loss carryforwards, state	$ 1,045,500
Tax credit carryforwards	$ 2,000
Tax credit carryforwards, expiration year	2024
Unrecognized tax benefits	$ 144,067	$ 110,601	$ 86,000	$ 41,074
Unrecognized tax benefits if recognized would impact effective tax rate	$ 0
Other States
Income Taxes [Line Items]
Net tax operating losses, expiration	begins to expire in 2030
Net operating loss carryforwards, state	$ 226,600
Domestic
Income Taxes [Line Items]
Net operating loss carryforwards subject to expiration	$ 65,200
Net tax operating losses, expiration	begin to expire in 2032
Net operating loss carryforwards not subject to expiration	$ 999,200
Research and development tax credit carryforwards	$ 18,000
Research and development tax credit carryforwards, expiration year	2032
State
Income Taxes [Line Items]
Net tax operating losses, expiration	begin to expire in 2032
Research and development tax credit carryforwards	$ 30,400