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Stockholders' Equity - Summary of Stock Option Activity (Detail) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Granted, Shares 2,643,378 2,641,125 2,535,425
Exercised, Shares (246,867) (268,938) (347,716)
2014 EIP and Inducement Plan      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Outstanding, Shares, beginning balance 7,851,886    
Granted, Shares 2,643,378    
Exercised, Shares (246,867)    
Forfeited or expired, Shares (1,028,560)    
Outstanding, Shares, ending balance 9,219,837 7,851,886  
Vested and expected to vest, Shares 9,219,837    
Exercisable, Shares 5,073,289    
Outstanding, Weighted Average Exercise Price, beginning balance $ 22.89    
Granted, Weighted Average Exercise Price 15.97    
Exercised, Weighted Average Exercise Price 13.97    
Forfeited or expired, Weighted Average Exercise price 25.92    
Outstanding, Weighted Average Exercise Price, ending balance 20.81 $ 22.89  
Stock options vested and expected to vest, Weighted Average Exercise Price 20.81    
Exercisable, Weighted Average Exercise Price $ 24.36    
Outstanding, Weighted Average Remaining Contractual Term 6 years 4 months 24 days 6 years 4 months 24 days  
Stock options vested and expected to vest, Weighted Average Remaining Contractual Term 6 years 4 months 24 days    
Exercisable, Weighted Average Remaining Contractual Term 4 years 9 months 18 days    
Aggregate intrinsic value $ 12,810 $ 26,834  
Vested and expected to vest, Aggregate Intrinsic Value 12,810    
Exercisable, Aggregate Intrinsic Value $ 5,496