Stockholders' Equity (Deficit) (Tables)

6 Months Ended

Jun. 30, 2025

Share-Based Payment Arrangement [Abstract]

Summary of RSU Activity

The following is a summary of RSU activity under our 2014 EIP, 2024 EIP and Inducement Plan:

	RSUs
	Shares			Weighted Average Grant Date Fair Value
Balance as of December 31, 2024		414,470		$	39.09
Granted		386,068		$	7.59
Forfeited		(13,910	)	$	75.15
Vested		(282,988	)	$	35.66
Balance as of June 30, 2025		503,640		$	15.87

Summary of Stock Option Activity

The following is a summary of stock option activity under our 2014 EIP, 2024 EIP and Inducement Plan:

	Shares			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value (in thousands)
Balance as of December 31, 2024		234,143		$	217.91		7.0	$	27
Granted		—			—		—		—
Exercised		—			—		—		—
Forfeited or expired		(46,594	)		259.30		—		—
Balance as of June 30, 2025		187,549		$	207.63		5.0	$	—

Schedule of Common Stock Reserved for Future Issuance Under Equity Incentive Plans

The following shares of common stock were reserved for future issuance under our equity incentive plans as of June 30, 2025:

	Total Shares Reserved
2014 Equity Incentive Plan		296,810
2018 Inducement Plan		150,589
2024 Equity Incentive Plan		381,996
2014 Employee Stock Purchase Plan		23,538
Total reserved shares of common stock		852,933

Schedule of Stock-based Compensation, Related to Employee and Nonemployee Stock Awards

The following is a summary of stock-based compensation expense for the periods presented:

	Three Months Ended June 30,				Six Months Ended June 30,
	2025		2024		2025		2024
	(in thousands)				(in thousands)
Research and development	$	742	$	3,314	$	2,340	$	8,027
General and administrative		2,060		3,022		4,670		6,706
Total stock-based compensation expense	$	2,801	$	6,336	$	7,010	$	14,733