Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets:
Net operating loss carryforwards	$ 259,376	$ 323,581
Capitalized research expenses	61,113	72,229
Tax credit carryforwards	8,216	30,580
Stock-based compensation	5,789	14,033
Deferred Revenue	14,709	17,018
Operating lease liabilities	9,403	12,035
License fees	4,794	5,926
Other	13,748	11,187
Total deferred tax assets	377,148	486,589
Valuation allowance	(368,401)	(474,982)
Total deferred tax assets	8,747	11,607
Deferred tax liabilities:
Operating lease assets	(8,747)	(11,607)
Total deferred tax liabilities	(8,747)	(11,607)
Net deferred tax assets (liabilities)	$ 0	$ 0