Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) shares in Thousands, $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive (Loss) Income	Accumulated Deficit
Beginning balance at Dec. 31, 2022	$ 126,640	$ 0	$ 1,821,731	$ (2,067)	$ (1,693,024)
Beginning balance (in shares) at Dec. 31, 2022		3,837
Issuance of common stock through ATM facilities, net of commissions and offering costs, value	2,172	$ 0	2,172
Issuance of common stock through ATM facilities, net of commissions and offering costs, shares		122
Exercise of pre-funded warrants, shares		116
RSU settlements, net of shares withheld	(94)		(94)
RSU settlements, net of shares withheld, shares		147
Issuance of common stock pursuant to employee stock awards	928		928
Issuance of common stock pursuant to employee stock awards, shares		36
Stock-based compensation expense	45,386		45,386
Net Income (Loss)	(276,126)				(276,126)
Unrealized gain (loss) on available-for-sale securities	1,863			1,863
Ending balance at Dec. 31, 2023	(99,231)	$ 0	1,870,123	(204)	(1,969,150)
Ending balance (in shares) at Dec. 31, 2023		4,258
Issuance of common stock through ATM facilities, net of commissions and offering costs, value	9,312		9,312
Issuance of common stock through ATM facilities, net of commissions and offering costs, shares		493
Exercise of pre-funded warrants, shares		9
RSU settlements, net of shares withheld	(7)		(7)
RSU settlements, net of shares withheld, shares		314
Issuance of common stock pursuant to employee stock awards	230		230
Issuance of common stock pursuant to employee stock awards, shares		26
Issuance of pre-funded warrants to purchase common stock through a registered direct offering, net of offering costs of $177, Shares		759
Issuance of pre-funded warrants to purchase common stock through a registered direct offering, net of offering costs of $397	50,603	$ 1	50,602	0	0
Stock-based compensation expense	27,001		27,001
Net Income (Loss)	(85,403)				(85,403)
Unrealized gain (loss) on available-for-sale securities	212			212
Ending balance at Dec. 31, 2024	$ (97,283)	$ 1	$ 1,957,261	$ 8	$ (2,054,553)
Ending balance (in shares) at Dec. 31, 2024		5,859