Stockholders' Equity (Deficit) (Tables)

12 Months Ended

Dec. 31, 2024

Share-Based Payment Arrangement [Abstract]

Summary of RSU Activity

The following is a summary of RSU activity under our 2014 EIP, 2024 EIP and Inducement Plan:

	RSUs
	Shares			Weighted Average Grant Date Fair Value
Balance as of December 31, 2023		250,709		$	158.00
Granted		548,990		$	13.76
Forfeited		(70,120	)	$	86.29
Vested		(315,109	)	$	79.06
Balance as of December 31, 2024		414,470		$	39.09

Summary of Stock Option Activity

The following is a summary of stock option activity under our 2014 EIP, 2024 EIP and Inducement Plan:

	Shares			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value (in thousands)
Balance as of December 31, 2023		428,786		$	290.75		6.5	$	—
Granted		16,500			11.00
Exercised		—			—
Forfeited or expired		(211,143	)		349.66
Balance as of December 31, 2024		234,143		$	217.91		7.0	$	27
Vested and expected to vest as of    December 31, 2024		234,143		$	217.91		7.0	$	27
Exercisable as of December 31, 2024		172,546		$	252.41		6.7	$	9

Summary of Options Estimated with Weighted Average

The fair value of each option issued was estimated at the date of grant using the Black-Scholes valuation model. The following table summarizes the weighted-average assumptions used as inputs to the Black-Scholes model and resulting weighted-average grant date fair values of stock options granted during the periods indicated:

	Year ended December 31,
	2024			2023
Assumptions:
Expected term (years)		5.5			5.8
Expected volatility		114.2	%		83.9	%
Risk-free interest rate		4.0	%		4.2	%
Expected dividend yield		0.0	%		0.0	%
Fair Value:
Weighted-average estimated grant date fair value per share	$	9.20		$	65.50
Options granted		16,500			187,756
Total estimated grant date fair value	$	151,800		$	12,298,010

Schedule of Common Stock Reserved for Future Issuance Under Equity Incentive Plans

The following shares of common stock were reserved for future issuance under our equity incentive plans as of December 31, 2024:

	Total Shares Reserved
2014 Equity Incentive Plan		554,974
2018 Inducement Plan		170,873
2024 Equity Incentive Plan		392,571
2014 Employee Stock Purchase Plan		23,731
Total reserved shares of common stock		1,142,149

Schedule of Stock-based Compensation Related to Stock Awards

The following is a summary of stock-based compensation expense for the periods presented:

	Year Ended December 31,
	2024		2023
	(in thousands)
Research and development	$	13,465	$	26,529
General and administrative		13,536		18,857
Total stock-based compensation expense	$	27,001	$	45,386