Condensed Consolidated Statements of Changes in Stockholders' Equity (Unaudited) - USD ($) $ in Thousands	Total	Common Stock	Common Stock At The Market Offering	Additional Paid-in Capital	Additional Paid-in Capital At The Market Offering	Accumulated Other Comprehensive Income	Accumulated Deficit
Beginning balance at Dec. 31, 2021	$ 279,614	$ 9		$ 1,744,695		$ (368)	$ (1,464,722)
Beginning balance (in shares) at Dec. 31, 2021		91,671
Issuance of common stock, net of commissions and offering costs, value	20,516				$ 20,516
Issuance of common stock, net of commissions and offering costs, shares			1,320
RSU settlements, net of shares withheld	(616)			(616)
RSU settlements, net of shares withheld, shares		405
Issuance of common stock pursuant to employee stock awards	96			96
Issuance of common stock pursuant to employee stock awards, shares		10
Stock-based compensation expense	14,335			14,335
Net (loss) income	(88,105)						(88,105)
Unrealized gain (loss) on available-for-sale securities	(1,524)					(1,524)
Ending balance at Mar. 31, 2022	224,316	$ 9		1,779,026		(1,892)	(1,552,827)
Ending balance (in shares) at Mar. 31, 2022		93,406
Beginning balance at Dec. 31, 2021	279,614	$ 9		1,744,695		(368)	(1,464,722)
Beginning balance (in shares) at Dec. 31, 2021		91,671
Net (loss) income	(153,730)
Unrealized gain (loss) on available-for-sale securities	(2,591)
Ending balance at Sep. 30, 2022	187,113	$ 9		1,808,515		(2,959)	(1,618,452)
Ending balance (in shares) at Sep. 30, 2022		94,879
Beginning balance at Mar. 31, 2022	224,316	$ 9		1,779,026		(1,892)	(1,552,827)
Beginning balance (in shares) at Mar. 31, 2022		93,406
RSU settlements, net of shares withheld	(3)			(3)
RSU settlements, net of shares withheld, shares		647
Issuance of common stock pursuant to employee stock awards	1,309			1,309
Issuance of common stock pursuant to employee stock awards, shares		303
Stock-based compensation expense	14,117			14,117
Net (loss) income	18,466						18,466
Unrealized gain (loss) on available-for-sale securities	(726)					(726)
Ending balance at Jun. 30, 2022	257,479	$ 9		1,794,449		(2,618)	(1,534,361)
Ending balance (in shares) at Jun. 30, 2022		94,356
RSU settlements, net of shares withheld	(4)			(4)
RSU settlements, net of shares withheld, shares		517
Issuance of common stock pursuant to employee stock awards	47			47
Issuance of common stock pursuant to employee stock awards, shares		6
Stock-based compensation expense	14,023			14,023
Net (loss) income	(84,091)						(84,091)
Unrealized gain (loss) on available-for-sale securities	(341)					(341)
Ending balance at Sep. 30, 2022	187,113	$ 9		1,808,515		(2,959)	(1,618,452)
Ending balance (in shares) at Sep. 30, 2022		94,879
Beginning balance at Dec. 31, 2022	126,640	$ 10		1,821,721		(2,067)	(1,693,024)
Beginning balance (in shares) at Dec. 31, 2022		95,927
Issuance of common stock, net of commissions and offering costs, value	590				$ 590
Issuance of common stock, net of commissions and offering costs, shares			148
RSU settlements, net of shares withheld	(93)			(93)
RSU settlements, net of shares withheld, shares		463
Stock-based compensation expense	11,764			11,764
Net (loss) income	(74,771)						(74,771)
Unrealized gain (loss) on available-for-sale securities	830					830
Ending balance at Mar. 31, 2023	64,960	$ 10		1,833,982		(1,237)	(1,767,795)
Ending balance (in shares) at Mar. 31, 2023		96,538
Beginning balance at Dec. 31, 2022	126,640	$ 10		1,821,721		(2,067)	(1,693,024)
Beginning balance (in shares) at Dec. 31, 2022		95,927
Net (loss) income	(215,676)
Unrealized gain (loss) on available-for-sale securities	1,496
Ending balance at Sep. 30, 2023	(50,838)	$ 10		1,858,423		(571)	(1,908,700)
Ending balance (in shares) at Sep. 30, 2023		101,922
Beginning balance at Mar. 31, 2023	64,960	$ 10		1,833,982		(1,237)	(1,767,795)
Beginning balance (in shares) at Mar. 31, 2023		96,538
Exercise of pre-funded warrants		2,916
RSU settlements, net of shares withheld	(1)			(1)
RSU settlements, net of shares withheld, shares		1,074
Issuance of common stock pursuant to employee stock awards	747			747
Issuance of common stock pursuant to employee stock awards, shares		574
Stock-based compensation expense	12,552			12,552
Net (loss) income	(71,108)						(71,108)
Unrealized gain (loss) on available-for-sale securities	304					304
Ending balance at Jun. 30, 2023	7,454	$ 10		1,847,280		(933)	(1,838,903)
Ending balance (in shares) at Jun. 30, 2023		101,102
RSU settlements, net of shares withheld, shares		820
Stock-based compensation expense	11,143			11,143
Net (loss) income	(69,797)						(69,797)
Unrealized gain (loss) on available-for-sale securities	362					362
Ending balance at Sep. 30, 2023	$ (50,838)	$ 10		$ 1,858,423		$ (571)	$ (1,908,700)
Ending balance (in shares) at Sep. 30, 2023		101,922