Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net operating loss carryforwards	$ 302,591	$ 308,997
Capitalized research expenses	50,522	10,499
Tax credit carryforwards	19,427	1,580
Stock-based compensation	19,201	24,181
Deferred Revenue	10,069	12,133
Operating lease liabilities	15,857	7,972
License fees	6,877	8,716
Other	13,169	9,414
Total deferred tax assets	437,713	383,492
Valuation allowance	(422,493)	(376,071)
Total deferred tax assets	15,220	7,421
Deferred tax liabilities:
Operating lease assets	(15,220)	(7,421)
Total deferred tax liabilities	(15,220)	(7,421)
Net deferred tax assets (liabilities)	$ 0	$ 0