<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2016-06-08</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001604416</issuerCik>
        <issuerName>Nexeo Solutions, Inc.</issuerName>
        <issuerTradingSymbol>NXEO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001478495</rptOwnerCik>
            <rptOwnerName>Wright Nathan H.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TPG GLOBAL, LLC,</rptOwnerStreet1>
            <rptOwnerStreet2>301 COMMERCE STREET, SUITE 3300</rptOwnerStreet2>
            <rptOwnerCity>FORT WORTH</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>76102</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>No securities beneficially owned</value>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Nathan H. Wright is a TPG Partner.  TPG is affiliated with (i) TPG VI Neon I, L.P. (&quot;Neon I&quot;), (ii) TPG VI Neon II, L.P. (&quot;Neon II&quot;), (iii) TPG VI FOF Neon, L.P. (&quot;FOF Neon&quot;) and (iv) Nexeo Holdco, LLC (&quot;Nexeo Holdco&quot; and, together with Neon I, Neon II and FOF Neon, the &quot;TPG Funds&quot;).  The TPG Funds directly hold an aggregate of 31,227,844 shares of common stock (&quot;Common Stock&quot;) of Nexeo Solutions, Inc. (the &quot;Issuer&quot;), as well as a right to future deferred payments in cash in lieu of receiving 5,654,960 additional shares of Common Stock.</footnote>
        <footnote id="F2">Mr. Wright disclaims beneficial ownership of all of the securities that are or may be beneficially owned by the TPG Funds or any of its affiliates. Pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;), this filing shall not be deemed an admission that Mr. Wright is, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any equity securities of the Issuer for purposes of Section 16 of the Exchange Act or otherwise.</footnote>
    </footnotes>

    <remarks>(3) David Reintjes is signing on behalf of Mr. Wright pursuant to the authorization and designation letter dated July 1, 2013, which is attached here as an exhibit.</remarks>

    <ownerSignature>
        <signatureName>/s/ David Reintjes on behalf of Nathan H. Wright (3)</signatureName>
        <signatureDate>2016-06-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
