Warrants, Warrants Exercisable (Details) - $ / shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Warrants Exercisable Price Range [Abstract]
Number of shares under warrants (in shares)	5,527,390
Weighted average remaining contractual life	3 years 11 months 12 days
Weighted average exercise price (in dollars per share)	$ 9.49	$ 12.20	$ 25.30
Exercise Price $0.00 - 9.99 [Member]
Warrants Exercisable Price Range [Abstract]
Warrants exercisable price range, minimum (in dollars per share)	0.00
Warrants exercisable price range, maximum (in dollars per share)	$ 9.99
Number of shares under warrants (in shares)	4,582,860
Weighted average remaining contractual life	4 years 1 month 13 days
Exercise Price $10.00 - 19.99 [Member]
Warrants Exercisable Price Range [Abstract]
Warrants exercisable price range, minimum (in dollars per share)	$ 10.00
Warrants exercisable price range, maximum (in dollars per share)	$ 19.99
Number of shares under warrants (in shares)	803,631
Weighted average remaining contractual life	3 years 6 months 14 days
Exercise Price $20.00 - 29.99 [Member]
Warrants Exercisable Price Range [Abstract]
Warrants exercisable price range, minimum (in dollars per share)	$ 20.00
Warrants exercisable price range, maximum (in dollars per share)	$ 29.99
Number of shares under warrants (in shares)	32,003
Weighted average remaining contractual life	1 year 6 months 21 days
Exercise Price $30.00 - 39.99 [Member]
Warrants Exercisable Price Range [Abstract]
Warrants exercisable price range, minimum (in dollars per share)	$ 30.00
Warrants exercisable price range, maximum (in dollars per share)	$ 39.99
Number of shares under warrants (in shares)	43,463
Weighted average remaining contractual life	6 months 25 days
Exercise Price $40.00 - 49.99 [Member]
Warrants Exercisable Price Range [Abstract]
Warrants exercisable price range, minimum (in dollars per share)	$ 40.00
Warrants exercisable price range, maximum (in dollars per share)	$ 49.99
Number of shares under warrants (in shares)	16,425
Weighted average remaining contractual life	3 months 7 days
Exercise Price $50.00 - 59.99 [Member]
Warrants Exercisable Price Range [Abstract]
Warrants exercisable price range, minimum (in dollars per share)	$ 50.00
Warrants exercisable price range, maximum (in dollars per share)	$ 59.99
Number of shares under warrants (in shares)	48,208
Weighted average remaining contractual life	4 months 24 days
Exercise Price $60.00 - 69.99 [Member]
Warrants Exercisable Price Range [Abstract]
Warrants exercisable price range, minimum (in dollars per share)	$ 60.00
Warrants exercisable price range, maximum (in dollars per share)	$ 69.99
Number of shares under warrants (in shares)	800
Weighted average remaining contractual life	5 months 1 day