X0306 4 2022-03-01 0001604191 First Wave BioPharma, Inc. FWBI 0001697536 Romano Sarah C/O FIRST WAVE BIOPHARMA, INC. 777 YAMATO ROAD, SUITE 502 BOCA RATON FL 33431 true Chief Financial Officer Stock option (right to buy) 1.18 2022-03-01 4 A 0 150000 0 A 2032-03-01 Common stock, par value $0.0001 per share 150000 150000 D The stock option vests in three equal annual installments commencing on March 1, 2023. /s/ Sarah Romano 2022-03-02